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For P450 enzyme inducers, hepatocellular hypertrophy is typically characterized ultrastructurally by proliferation of smooth endoplasmic reticulum (Figure 2) that on HandEstained light microscopy sections is manifested as enlarged hepatocytes with finely granular or ground glass eosinophilic cytoplasm (Figure 3)

Given that oxaliplatin treatment results in mitochondrial dysfunction and excess production of ROS, it seems probable, therefore, that anti-oxidative stress compounds protect against PN by scavenging excess ROS and/or by inducing Nrf2-based antioxidant transcription

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