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Regarding long-term exploration through post hoc analysis of the ECLAT study, a 12-month prospective, randomized, controlled, double-blind trial in smokers with no intention to quit tobacco smoking who switched to e-cigarettes with and without nicotine, it was found that those who switched to e-cigarettes experienced a statistically significant reduction in long-term systolic blood pressure, with this reduction being more pronounced in smokers with elevated baseline blood pressure (35)

Some new devices with lower resistance, higher voltage, and e-liquid nicotine concentration produce nicotine levels in the blood comparable to tobacco cigarettes [108, 109]