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Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig

Overall, the available data support a cautious model in which mitochondria in the apical domain of PACs function as local ATP suppliers and Ca 2+ buffers that help maintain the secretory apparatus under physiological conditions, whereas mitochondrial failure in AP may indirectly destabilize the granule-rich apical region and facilitate pathological zymogen activation

Amino acids enhance performance by dilating blood vessels to improve blood flow, mobilizing fat stores to burn energy efficiently, and reducing lactic acid build up and muscle pain post-exertion

Funding This paper is supported by program E022 of the National Institute of Pediatrics