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Straus DS, Pascual G, Li M et al (2002) 15-Deoxy-Delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway

Certain handling mistakes degrade the molecule, reduce potency, or contaminate the solution

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The result can include: Reduced receptor binding Lower biological activity Molecular fragmentation Loss of analytical purity Oxidation is accelerated by: Light Heat Air exposure Metal contamination Deamidation Certain amino acid sequences undergo spontaneous deamidation after reconstitution