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The Gsh1 and Gsh2 of conventional GSH biosynthetic pathway or the bifunctional GshF reported previously have been independently modulated for GSH production

However, the exact role of GST enzymes in the mechanism of ISR is still far from elucidated because transgenic plants overexpressing or suppressing the symbiont-inducible GSTs have been rarely studied (Kao et al., Conclusions and Future Perspectives Since the beginning of plant GST research in 1970 the fundamental questions have remained largely unanswered: what are the physiological roles of GST isoenzymes and which metabolites are the natural, endogenous substrates of GSTs

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Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, currently without UK marketing authorisation from the MHRA or EMA