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This is the single strongest piece of physiology behind the blend concept and, importantly, it is established GH physiology from controlled endocrine studies of the individual agents, not a validated finding about the specific CJC-1295 + Ipamorelin co-formulation

doi: 10.1016/S0076-6879(94)33026-3 20 MartnezMCAndriantsitohainaR

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pulsatility as well as sustained, dose-dependent increases in [growth hormone] and IGF-I levels in healthy adults.11 9 In 1999, a human trial with 40 total volunteers concluded that ipamorelin at multiple doses induces growth hormone secretion at sufficient levels to be biologically effective, with peak concentration arriving within an hour.12 These studies examined the two peptides separately, but their results validate the mechanisms of action that underlie the reason that CJC-1295 and ipamorelin are used together