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After JAK kinase is activated, it phosphorylates and dimerizes STAT proteins enters the nucleus, and binds to the regulatory region of specific genes, promoting the transcription of SASP-related genes (such as IL-6 and IL-8) by forming a vicious cycle of inflammatory factor-activation of the JAK-STAT pathway-inflammatory factor storm

It binds to harmful toxins, heavy metals, and other pollutants, facilitating their excretion from the body

Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB