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Per the applicant, TERLIVAZ is a pharmacologic therapy administered via IV bolus for the treatment of hepatorenal syndrome (HRS) with rapid reduction in kidney function

LPS itself has multiple adverse effects on the gut function, promoting intestinal inflammation and disrupting tight junctions (TJ) organization via specific signaling pathways which determines directly enterocytes shedding without compensatory TJ- releasing, and induces oxidative stress in epithelial cells, mitochondrial failure, and mitophagy [22]

Key Takeaway: Bloating from collagen is usually a physical reaction to the protein attracting water or the digestive system working to break down large molecules

Hirata et al., 2012)