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We highlight several ongoing controversies in the field, and discuss the role of the microbiome in modulating the availability of NAD + precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), the presence of multiple cellular compartments that have distinct pools of NAD + and NADH, and non-canonical NAD + and NADH degradation pathways

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References Li BUK, Lefevre F, Chelimsky GG, Boles RG, Nelson SP, Lewis DW, Linder SL, Issenman RM, Rudolph CD: NASPGHAN Consensus Statement on the Diagnosis and Management of CVS