Microbiota-targeted strategies are considered within a lifestyle and nutritional modulation framework for healthy aging, while their potential role as therapeutic adjuncts is discussed in relation to specific clinical conditions, such as metabolic or inflammatory disorders, where emerging but still limited evidence is available
Suppression of HIF-PH in cultured Drosophila melanogaster cells by RNA interference resulted in elevated expression of a hypoxia-inducible gene (encoding lactate dehydrogenase) under normoxic conditions, indicating that HIF-PH is an essential component of the pathway through which cells sense oxygen
Through a variety of mechanisms, including the regulation of cell behaviors like proliferation, differentiation, increased maturation and apoptosis, autophagy, and epithelial-mesenchymal transition (EMT), as well as the modulation of interactions between cells and their microenvironment, such as the suppression of inflammation, the immune system, angiogenesis, and anti-oxidants, vitamin D can control tumor cells (64)
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