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383 SIRT5-catalyzed demalonylation and inactivation of SDHA block the TCA cycle and induce succinate accumulation, promoting tumorigenesis and drug resistance

if a duct is blocked (by a gallstone, scar-like narrowing/stricture, or a tumor), the drug cant reach its target and adding more bile acids can worsen the backup (jaundice, itching, rising bilirubin/ALP)

This reaction directs glucose to glycolysis, the only pathway for metabolism of Fru-1,6-BP

Storage Recommendations for Research Use: Store lyophilized BPC-157 at -20C in a sealed, desiccated environment Once reconstituted for laboratory use, maintain at 28C and utilize within established research protocol timeframes Avoid repeated freeze-thaw cycles to preserve peptide integrity for research purposes Keep away from UV light exposure during storage For reconstitution, use sterile bacteriostatic water