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The amount of the test item and the volume of the formulations prepared varied depending on the requirements and/or body weight of the animals

Among them, oxidative stress refers to the excessive accumulation of reactive oxygen species (ROS) that leads to the imbalance of oxidants and antioxidants, oxidative stress has the ability to lead to mitochondrial dysfunction and lysosome dysfunction, and ultimately induces neurodegenerative disease (Caspersen et al., 2005

Cystathionine -synthase and cystathionine -lyase, which are PLP-containing enzymes, can use cystine to form the LMW cysteine persulfide through ,-elimination (Yadav et al., 2016)

Cell Death Dis 13(7):592 Goodwin JM, Dowdle WE, DeJesus R, Wang Z, Bergman P, Kobylarz M, Lindeman A, Xavier RJ, McAllister G, Nyfeler B et al (2017) Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9