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It differs from native IGF-1 by having an arginine substitution at the third amino acid (R3) and an additional 13 amino acids at the N-terminus, making it significantly more potent in receptor activation studies

*Correspondence: Dongyi He, [email protected] This article was submitted to Autoimmune and Autoinflammatory Disorders: Autoimmune Disorders, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Abbott, United States of America) following a 6-h fasting period