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Kong L, Wang Y, Luo M, Tan Y, Cui W, Miao L

Subcutaneous administration suffers from: Lower bioavailability Variable absorption Different pharmacokinetics Which means the systemic exposure of DSIP via subcutaneous administration is not equivalent to what is achieved with intravenous infusion

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The newer, much larger sibling-comparison results suggest those earlier signals may largely reflect background family factors rather than a direct drug effect