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Disease-modifying strategies include delivering glial cell line-derived neurotrophic factor (GDNF) to support neuronal survival, while non-disease-modifying approaches aim to enhance dopamine production by increasing the expression of enzymes like aromatic L-amino acid decarboxylase (AADC) and tyrosine hydroxylase [167]

CagriSema is the investigational fixed-combination of cagrilintide with the GLP-1 receptor agonist semaglutide studied across the Phase 2 and Phase 3 REDEFINE trials