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Helicobacter pylori induces somatic mutations in 53 via overexpression of CHAC1 in infected gastric epithelial cells

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor studied for its effects on NAD+ metabolism, cellular energy regulation, and adipose tissue models in preclinical research

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Together, our complementary omics analyses of eWAT in obese mice reveal a striking tissue remodelling and metabolic reprogramming upon an IF regimen, whereas eWAT seems refractory to most of these IF-mediated changes when p53 is depleted in adipocytes