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92 Endogenous enzymes (Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx)) and non-enzymatic molecules such as Reduced Glutathione (GSH), melatonin, and coenzyme Q10 (ubiquinone), aid in keeping free radicals in a homeostatic state

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Methylglyoxal impairs energy production and the anti-oxidative protective effects, thereby contributing to the enhanced PS exposure of circulating erythrocytes and ultimately resulting in anemia and microcirculatory disequilibrium [321]