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The fact, however, that OvSH exists as thiolate nearly throughout the pH scale, explains its wide pH range antioxidant potency compared to conventional thiols such as glutathione (latter is inherently a stronger reducing agent, but it exists mostly in the inactive protonated form at neutral pH and below)
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Adding vitamin C to a glutathione infusion therefore amplifies the antioxidant effect in two ways: it adds a powerful antioxidant in its own right, and it extends the working life of the glutathione already in circulation
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