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A deficiency in either of these vitamins can cause a wide range of problems, including: extreme tiredness a lack of energy pins and needles a sore and red tongue mouth ulcers muscle weakness problems with your vision psychological problems, which can range from mild depression or anxiety to confusion and dementia problems with memory, understanding and judgement Some of these problems can also happen if you have a deficiency in vitamin B12 or folate but do not have anaemia

The dosing is gradually increased over time to reduce the chance of gastrointestinal discomfort, which is common during early weeks of treatment

Proksch E, Zdzieblik D, Oesser S