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The lethal dose in humans would be approximately 21,000mg for a 70kg person, making the 1-3mg daily doses used in typical protocols extremely safe from a toxicity standpoint

Horm Res Paediatr

Pharmacological inhibitors targeting caspase-1 activity have been investigated for their potential to dampen the inflammatory response and reduce tissue damage in APAP-induced liver injury

Better measurement precision at a larger amount is not an argument for using a larger amount under a non-monotonic dose-response, a precisely measured wrong dose is still a wrong dose