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Description

Formononetin upregulates Nrf2/HO-1 signaling and prevents oxidative stress, inflammation, and kidney injury in methotrexate-induced rats

10.1111/j.1600-0536.2008.01442.x

Oxidative stress, characterized by the accumulation of excess reactive nitrogen species (RNS), reactive oxygen species (ROS), and other reactive metabolic intermediates, causes damage to DNA, RNA, lipids, proteins, and other molecules [19]