Cell 69, 227237.e4
This just-formed superoxide, together with its reduced metabolites, can interact with a great number of different naturally occurring body biomolecules, at least partially leading to the development of many diseases such as cardiovascular disease, cancer, chronic inflammation, dementia, and amyotrophic lateral sclerosis, among others [140,141]
Investigations into peripheral immunity in ASD generally reveal an inflammatory profile, with IL-17A and IL-16 (and, in some cases, IL-9) representing key mediators reported to differ from controls 2,3,9,10,11
The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents