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Upregulated genes were enriched in pathways related to the DNA damage response and glutathione metabolism, implying oxidative stress-induced DNA damage

How reactive metabolites induce an immune response that sometimes leads to an idiosyncratic drug reaction

Dysfunction of the carnitine transporter OCTN2 is the cause of Primary Carnitine Deficiency (PCD), which is characterized by systemic loss of carnitine with severe clinical manifestations, including fertility issues in both males and females