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The study identified the 2.4 mg dose as optimal for combination development based on efficacy-tolerability balance

As a result, many widely prescribed medications are capable of harming mitochondria in the following ways: Inhibiting Mitochondrial DNA Production Some medications interfere with mitochondrial DNA synthesis, disrupting the production of proteins necessary for energy production (ATP synthesis)

The next day, cells were washed three times with PBS, then were incubated with 4,6-diamidino-2-phenylindole (DAPI, 1 g/mL) during 5 min at RT

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