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Limitations The overview approach we used for interventions other than e-cigarettes comes with limitations, as we relied on what was reported in the Cochrane systematic reviews

Although this is a dramatic drop, tobacco companies might try to find other ways to make cigarettes appealing

Liver disease was also found to be a significant risk factor for APE (aOR 1.37), possibly due to a combination of hypoalbuminemia, fluid overload, systemic inflammation, and coagulopathy resulting from impaired hepatic synthesis of clotting factors, all of which can increase pulmonary capillary leakage and predispose to edema [24]

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