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Moreover, astrocyte-derived neurotrophic factors are considered valuable targets for AD and ischemic stroke, as they stimulate astrocyte-mediated neurogenesis and angiogenesis or enhance their neuroprotective profiles through growth factors and antioxidants 124,127

Combining them might to offer the benefits of both without significantly increasing the risk of adverse effects

However, the limited bioavailability of glutathione due to rapid degradation hinders its delivery to the lens

L-T4 therapy has been shown to reduce the prevalence of MASLD, especially in patients with severe SCH or mild SCH patients with dyslipidemia, and these patient populations should be prioritized for active clinical intervention