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It seems that while the negative feedback of the STAT3 signaling delays the insulin/IGF-1-induced aging process, it nonetheless elicits insulin resistance and diabetes

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Borges F., Fernandes E., Roleira F

However, excessive production of ROS is involved in various stages of the pathogenesis of thyroid diseases and activates possible common triggers of GD and HT, differentiated thyroid cancer and even endemic goiter (64)

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