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The above observation suggests that a hominid species or a modified mouse carrying the human Met gene seems essential, to examine the human therapeutic efficacy of these dimeric macrocycles in future animal experiments

Cats lack the necessary glucuronyl transferase enzymes to safely break paracetamol down and tiny fractions of a normal tablet for humans may prove fatal.[51] Initial symptoms include vomiting, salivation and discolouration of the tongue and gums

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However, in another prospective randomized comparative study, NB-UVB proved to be statistically more efficacious at achieving disease stability compared to minocycline 100 mg once daily monotherapy for the treatment of unstable vitiligo to be statistically more efficacious and better at achieving disease stability than minocycline (100 mg/day) monotherapy for unstable vitiligo (disease stability in 76.1% of NB-UVB group versus 33.3% in minocycline group)