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Moreover, under conditions of high folate intake, 5-methylTHF reduces the alternative transmethylation pathway by inhibiting glycine methyltransferase (Fig

In this study, we revealed a significantly altered metabolic profile and immune responses in the peripheral system of Chinese patients with MS, in which metabolites of amino acids and sphingolipids might not only modulate peripheral proinflammatory responses but also drive the inflammatory process within the CNS