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Among the three drugs, GLP-3R demonstrated the greatest reduction in inflammation and fibrosis marker expression, suggesting its superior efficacy in delaying the progression of DKD

Author Contributions Conceptualisation, N.Y., P.W.R.H., J.W

As discovered more recently by Zhangs group, NRF2 can also be negatively regulated through the E3 ubiquitin-protein ligase synoviolin (HRD1), recently associated with the ER stress produced by misfolded protein accumulation