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Tirzepatide, in particular, has shown impressive results in clinical trials, with participants losing up to 22.5% of their body weight over 72 weeks

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Rodrguez-Rodrguez et al., 2014) such as myeloperoxidase, a heme enzyme secreted by human artery wall macrophages which oxidizes apolipoprotein A-I (apoA-I), the major HDL protein, diminishing apoA-I ability to promote cellular cholesterol efflux