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There was also no evidence on adverse effects identified in our overview of reviews

This change closes a loophole that previously allowed ENDS manufacturers to change their formulationor claim that they were doing so without FDA investigationand continue to freely sell virtually identical products targeting youths

3 However, although tobacco combustion byproducts are considered more harmful than nicotine for nonpregnant adults, nicotine itself is a developmental toxicant when used during pregnancy and is characterized by the FDA as teratogenic to human fetuses

They also would like to be given a better defined timeline to anticipate changes before such laws take effect