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8-week on, 4-week off example: Weeks 1-2: Assessment and dose finding (every other day) Weeks 3-6: Optimization phase (3-5 times weekly) Weeks 7-8: Maintenance (3 times weekly) Weeks 9-12: Complete break, no DSIP During the off period, focus on sleep hygiene fundamentals: consistent wake times, light exposure management, temperature optimization, and stress reduction

Wang S, Lei Z, Chen S, Xiang A, Zou Y, Liu Y (2024b) Dioscin exerts nephroprotective effects by attenuating oxidative stress and necroptosis-induced inflammation

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The reduced form is the predominant one and GSSG is maintained at low levels, less than 1% mainly by the action of NADPH-dependent glutathione reductase [13], which converts GSSG into the reduced GSH (Figure 1)