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Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine

Preparation Condition 2 (EDTA deproteinization 80 o C): Anticoagulants used during collection impacts measures of GSH Suggesting the anticoagulant used during sample collection significantly alters plasma GSH, we found lower levels of free GSH, higher levels of GSSG, and a lower ratio of free GSH to GSSG in the heparinized plasma (Preparation Condition 1) compared to the EDTA-treated plasma (Preparation Condition 2)

Research indicates that lower GSH is associated with higher oxidative stress

USA 98 , 87808785 (2001)