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Antibiotic Prophylaxis in Cardiac Conditions Cardiac condition Indication for antibiotics All cardiac conditions Highest risk of IE No If established GI tract infection and for those who receive antibiotic therapy to prevent wound infection or sepsis associated with a GI procedure, use an antibiotic regimen with an agent active against enterococci NA Prosthetic cardiac valve History of IE Cardiac transplant with valvulopathy CHD Unrepaired cyanotic CHD Repaired CHD (first 6 mo) Repaired CHD with residual defects Abbreviations: CHD, congenital heart disease

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