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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

In fact, vitamin B12 deficiency is a known contributor to neural tube defects

Research suggests benefits for inflammatory bowel conditions, gastric ulcers, esophageal damage, and gut lining integrity

Maintaining adequate folate levels is crucial for overall health and can help prevent megaloblastic anemia and age-related macular degeneration