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These convert phosphatidylinositol2-phosphate (PIP2) into phosphatidylinositol-3-phosphate (PIP3) and, by so doing, activates protein kinase B (PKB), the metabolic pathway for glycogen synthesis.1314 In addition to the conversion to phosphatidylinositol-3-phosphate, inositol also acts by activating pyruvate dehydrogenase kinase, isoenzyme 1

This is further supported by observations that the frequent oligoclonal immunoglobulins produced behind the blood brain barrier in MS may be non-specific, targeting general cellular debris (Brndle et al., 2016

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