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Abstract Glutathione is a tripeptide that plays a pivotal role in critical physiological processes resulting in effects relevant to diverse disease pathophysiology such as maintenance of redox balance, reduction of oxidative stress, enhancement of metabolic detoxification, and regulation of immune system function

MTHFR, or the methylenetetrahydrofolate reductase is the key regulatory enzyme in folate and homocysteine metabolism

Known as the master antioxidant, it plays a critical role in detoxifying the liver, supporting immune function, and improving skin health

The 15-amino-acid fragment designated BPC-157 was selected for study because it retained the cytoprotective properties of the parent protein while being amenable to chemical synthesis at research-grade purity a practical advantage that has enabled three decades of systematic preclinical investigation