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Healthcare providers often need to reduce the doses of these concurrent antidiabetic medications when starting semaglutide therapy, with subsequent adjustments based on glucose monitoring results and clinical response

When switching from oral to injectable, reduce your dose by approximately 50-60% initially and adjust based on response

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Nicotinamide N-methyltransferase (NNMT) inhibition increases energy expenditure and decreases fat storage, two important aspects of treating insulin resistance, a defining feature of type 2 diabetes