In laboratory models, it is frequently investigated alongside other metabolic analytes to see how they work together to synchronize neuroendocrine signals
Through another transcription factor by the name of p53: p53 is a homo-tetrameric transcription factor composed of an N-terminal trans-activation domain (TAD, residues 161), a prolin-rich domain (PR, residues 6492), a central DNA-binding domain (DBD, residues 93293) followed by a tetramerization domain (TD, residues 325355) and the C-terminal negative regulatory domain (NRD, residues 367393) (Fig
Upon CCCP treatment, Miro interacting with wild-type LRRK2 was degraded with time, while in the LRRK2 G2019S mutant, Miro showed decreased interaction with the mutant as well as resistance to degradation, delaying mitochondrial arrest and clearance in iPSC-derived neurons (Hsieh et al., 2016)
It is also found in plants , animal cells , and fungi