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1 (2023.) Yadav, S., Chauhan, M., Jacob, M

Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

Glutathione IV therapy helps replenish these levels quickly and effectively by delivering the antioxidant directly into the bloodstream

In addition, it represents an effective therapy in improving the quality of life of patients affected by various disorders