As a damage-associated molecular pattern (DAMP), HMGB1 activates immune cells to amplify inflammation through the release of multiple cytokines or chemokines[107]
Clinicians across sports medicine, orthopedics, gastroenterology, and integrative health now prescribe these compounds for tendon and ligament repair, gut-lining restoration, and systemic anti-inflammatory support
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The translatability of ferroptosis-targeted therapies from mice to humans is thus uncertain, for example, whether human LN immune cells exhibit the same ferroptosis susceptibility as mouse models, or if species-specific differences in ferroptosis regulators (e.g., FSP1 vs
