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Finally, individuals with compromised liver or kidney function, or those with severe gastrointestinal diseases like Crohn's or ulcerative colitis, require highly modified protocols

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BPC-157 does not directly improve sleep through hormonal mechanisms, though reducing chronic pain or inflammation may indirectly improve sleep quality in patients whose sleep is disrupted by physical discomfort

And to show we're not making this stuff up: The mechanisms underlying these effects involve multiple cellular targets to elevate brain-derived neurotropic factor (BDNF) levels, reduce microglia activation, and decrease levels of proinflammatory mediators So...we have both the growth side (BDNF and neurogenesis) and protection from the insulting side (microglia hyperactivation and inflammation)