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Similarly, models with significant kidney or liver dysfunction are generally unsuitable, as impaired peptide clearance may heighten the risk of adverse effects

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Oral bioavailability for Dihexa has been estimated at 4060% in animal models, substantially higher than most peptides which typically show less than 5% oral absorption due to first-pass metabolism and enzymatic degradation in the gastrointestinal tract

Similarly, changes in expression levels of proteins responsible for translation, including Pabpc1, Eif3f, and Eif5a, among other factors, have been associated to SCA3 pathology