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All antibiotic and GSH treatment solutions were prepared in 1 PBS (pH 7.4)

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Changes of flux in any one of these pathways will influence pyruvate concentration and thus directly affect lactate concentration as the two are maintained close to thermodynamic equilibrium

Renal fibrosis, the terminal pathological manifestation of most chronic kidney diseases (CKD), is a multifactorial process driven by extracellular matrix (ECM) dysregulation, fibroblast-to-myofibroblast transdifferentiation, immune cell infiltration, and tubular epithelial-mesenchymal transition (EMT)(Figure 1)