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PE-22-28 doubled the number of BrdU-positive cells, a direct marker of neurogenesis

It is undeniable that the combination of novel AIE PSs and 2D materials provided conducive insight into exploiting multimodal theranostic systems for cancer in which PDT is integrated with image guiding via novel PSs

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The human results are mixed, with small open-label studies encouraging but the controlled phase 2 OVERTURE trial missing its primary endpoint, and the larger pivotal trial has finished enrolling with results pending, so for now it is best read as mechanistically promising and clinically unproven