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Yet, the short duration of the study did not permit a conclusion on whether the lowering of homocysteine through B-vitamin supplementation could have long-term benefits on bone strength and fracture risk (119)

Nevertheless, as the phenotypes caused by most yeast prions result from loss-of-function of a protein, which already performs a distinct molecular role in its native state, the functional character of the yeast prions has been contested and an alternative view presents them as analogous to human amyloidosis and other prion diseases (Wickner et al., 2011)