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Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes

By methylating and removing nicotinamide, NNMT effectively drains NAD+ precursor availability, leading to reduced intracellular NAD+ levels

in the absence of validated data, a conservative approach is appropriate discard sooner rather than later if there is any doubt Lyophilised (unreconstituted) vials should be stored according to the supplier's or trial protocol's instructions