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In addition to their classical phagocytic and digestive functions, macrophages, like neutrophils, can also act produce a network of granular proteins and DNA called macrophage extracellular traps (METs), in response to specific stimuli [14, 15]

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Therefore, when a procedure code describing an appendectomy is reported with principal diagnosis code K35.21, the logic for case assignment to MS-DRGs 338, 339, or 340 is satisfied