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Researchers select format based on route of administration requirements and whether the protocol calls for fixed or variable dosing across experimental arms

Development involved developing matrix and drug reservoir type transdermal patches using i) several polymers such as Polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly(Butyl methacrylate, methyl methacrylate), cellulose (Ethyl cellulose, Hydroxypropylmethylcellulose Polyvinylpyrrolidone etc

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While it has been studied for decades, it has never advanced into full pharmaceutical approval